Nationally recognized for its public exhibits and collections, research and graduate education, the museum's exhibits focus on the biological diversity of the Great Plains. Fossil exhibits profile extinct mammals, dinosaurs, reptiles and fish. The museum's panorama, one of the world's largest dioramas, features scenes ranging from arctic to tropical habitats. Living exhibits include a working beehive and Kansas snakes. The museum is home to Comanche, a U.S. Seventh Cavalry horse that survived the 1876 Battle of the Little Bighorn, and a 60-foot-long Mosasaur – one of the great "sea monsters" of Kansas. "Bugtown" features live insects and interactive exhibits that explore the world from a bug's point of view.
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